You know the drill - comics I read, crap I look at, sites I use and frequent.

Webcomics Description
Questionable Content Arguably the Neighbours of webcomics, still a good read.
Shortpacked Excellently weird comic about toyshop employees...
Edible Dirt Single-panel comics that are so wrong, they're right.
Flem Comics One of the most disgustingly funny comics I've ever seen. Beware the Jay Series.
Nice Hair What do you get when you put a bunch of goth creators in a house? Improbable adventures, baffling German superheroes, and of course, exquisite hairdos.
Penny Arcade Comics about gaming, gamers, gamers on gaming, games on gamers....
Sexy Losers Proving Interweb Rule #1 - no matter how sick it is, someone else has already thought of it. And in this case, written a comic about how funny it is, too.
Two Lumps The best cat comic I've seen since Fat Freddy's Cat.

Irish webcomics

A Thought For A Day by Rory Glynn  
The Amazing Squad by Michael Arbuthnot  
Atomic Soup by David Keeling  
Bifsniff Comics  
Big If Comics  
Chris Judge  
Clamnuts  
Declan Shalvey  
Dog Sharkey  
Don & Doll by Dolores Fogarty & Adrian Mee
Drastic Comics by Adam Murray and Gill Smyth
Dublin Zoo by Kevin Thompson
Fyshbowl Comics by Kyle Rogers
Legend Of Bee by CD Lynch
Matchstick Cats
Neko The Kitty by Gearoid Molloy
Ponchomania
Press Start To Play by Adam Law and Darryl Walker
Robbie Bonham

Irish Sites

 
Lost Carpark Good resource for links to all things sci-fi, fantasy & horror in Ireland.
Irish SF News Fairly comprehensive Irish Sci-fi news site, which also features periodic updates on the Irish comic scene. 
Mongrel New student-type magazine (in both online and printed forms) which includes comics by Bob Byrne and Chris Judge.
Boards.ie Comic Forum Comic forum where I and other Irish comics folk lounge around, or whatever the internet equivalent is.
GetYourComics.Com Cork-based online comics store.
Other Realms Website for my local comic store.

Fyshbowl Comics is hosted on ComicGenesis, a free webhosting and site automation service for webcomics.